Abstract: Slurry preprocessing is a crucial step before flotation operations, and its energy input significantly affects the adsorption efficiency between coal slime particles and flotation reagents. An orthogonal experimental method is used to investigate the optimal process conditions for conditioning time, mechanical agitation intensity, and collector dosage in flotation kinetics. A flotation kinetics energy adaptation model for different particle size fractions of coal slime is established. Utilizing the orthogonal experiments, the significant impact of conditioning time, agitation intensity, and collector dosage on flotation performance is determined, and the optimal factor levels are identified. The order of significance is: conditioning time > collector dosage > stirring speed. The optimal factor combination scheme for conditioning is determined as: conditioning time of 40 s, collector dosage of 2.07 g per ton of dry coal slime, and stirring speed of 500 r/min. The influence of each factor on flotation indicators is also examined. The research results aim to provide theoretical guidance for reducing energy consumption and reagent waste in coal slime flotation, and to offer theoretical support for coal preparation plants to improve flotation equipment and enhance flotation efficiency.